Exploring the diagnostic and immune infiltration roles of disulfidptosis related genes in pulmonary hypertension
We uncovered the distinct expression patterns of DiGs in PH, identified core genes utilizing an XGB machine-learning model, and established a CeRNA network. Drugs targeting the core genes were predicted and subjected to molecular docking. Experimental validation was also conducted for these core genes.
Authors
- Pinfang Kang (ORCID: https://orcid.org/0000-0001-7084-7862)
- Yiyao Zeng
- Bi Tang (ORCID: https://orcid.org/0000-0001-6059-6713)
- Ningning Zhang (ORCID: https://orcid.org/0009-0000-6805-5962)
- Xin Tan (ORCID: https://orcid.org/0000-0003-3785-9700)
- Shuai Xu (ORCID: https://orcid.org/0000-0001-7919-2874)
- Hongju Wang (ORCID: https://orcid.org/0000-0002-1662-485X)
- Huimin Fan
- Ge Zhang (ORCID: https://orcid.org/0009-0002-7012-2655)
- Fenlan Bian
- Yafeng Zhou
- Jili Fan
- Xiaohong Bo
- Yangjun Fu
Institutions
- Bengbu Medical College (CN)
- Henan University of Technology (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- First Affiliated Hospital of Soochow University (CN)
- Third People's Hospital of Hefei (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Henan Provincial Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1186/s12931-024-02978-w
- Citations
- 5
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Natural Science Foundation of China
- Anhui University
- Government of Jiangsu Province