Novel H-2D<sup>b</sup>-restricted CD8 epitope derived from mouse MAGE-type antigen P1A mediates antitumor immunity in C57BL/6 mice
We identified the first CD8<sup>+</sup> T-cell epitope of the MAGE-type P1A tumor antigen presented in the H-2<sup>b</sup> background. This opens new perspectives for mechanistic studies dissecting MAGE-type specific antitumor immunity, making use of the wealth of genetically altered mouse strains available in the C57BL/6 background. This should facilitate the advancement of specific cancer immunotherapies.
Authors
- Vinnycius Pereira Almeida (ORCID: https://orcid.org/0000-0002-3635-7787)
- Maryam Ahmad (ORCID: https://orcid.org/0000-0003-4697-0523)
- James McAuliffe (ORCID: https://orcid.org/0000-0002-4858-3191)
- Vineethkrishna Chandrasekar (ORCID: https://orcid.org/0000-0002-0927-9154)
- Nathalie Vigneron (ORCID: https://orcid.org/0000-0002-2761-2803)
- Laurine Noblecourt (ORCID: https://orcid.org/0009-0002-8710-6846)
- Emily E Steffke (ORCID: https://orcid.org/0000-0003-3350-9818)
- Benoı̂t J. Van den Eynde (ORCID: https://orcid.org/0000-0002-4995-3270)
- Ramiro A. Ramirez-Valdez
- Amanda Wicki (ORCID: https://orcid.org/0009-0001-7779-932X)
- Carol Sze Ki Leung (ORCID: https://orcid.org/0000-0002-1545-7228)
- Julie Lesenfants
- Vincent Stroobant
- Silvia Panetti (ORCID: https://orcid.org/0000-0003-0176-7636)
- Yushu Hu
- Shi Yu William Guo
Institutions
- University of Verona (IT)
- Ludwig Cancer Research (BE)
- University of Oxford (GB)
- Ludwig Cancer Research (GB)
- de Duve Institute (BE)
- Walloon Excellence in Lifesciences and Biotechnology (BE)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1136/jitc-2024-008998
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- National Science Foundation
- Ludwig Institute for Cancer Research
- Cancer Research UK
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung