Serological Responses to Target <i>Streptococcus pyogenes</i> Vaccine Antigens in Patients With Proven Invasive β-Hemolytic Streptococcal Infections
Patients with invasive Strep A infection mount robust antibody responses to 6 non-M protein vaccine candidate antigens. Similar significant responses to C5a peptidase in those with invasive SDSE and GBS infection highlight the importance of further research into cross-species protection and immunological correlates of vaccine efficacy.
Authors
- Laurens Manning (ORCID: https://orcid.org/0000-0003-4334-5351)
- Alma Fulurija (ORCID: https://orcid.org/0000-0003-1776-785X)
- Siong Hui (ORCID: https://orcid.org/0009-0009-3477-6759)
- Avram Levy (ORCID: https://orcid.org/0000-0002-0934-2387)
- Edward Raby (ORCID: https://orcid.org/0000-0003-1671-6188)
- Daniel R. Knight (ORCID: https://orcid.org/0000-0002-9480-4733)
- Michael Morici (ORCID: https://orcid.org/0000-0001-7101-0976)
- Kristyn Langworthy (ORCID: https://orcid.org/0000-0002-6953-8664)
- Michael Taggart (ORCID: https://orcid.org/0000-0002-4441-8105)
- R. Smith (ORCID: https://orcid.org/0000-0003-2649-2077)
Institutions
- The Kids Research Institute Australia (AU)
- The University of Western Australia (AU)
- Curtin University (AU)
- Western General Hospital (GB)
- Fiona Stanley Hospital (AU)
- Fremantle Hospital (AU)
- Queen Elizabeth II Medical Centre (AU)
- Pathwest Laboratory Medicine (AU)
- Fiona Stanley Fremantle Hospitals Group
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1093/infdis/jiae496
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Government
- University of Western Australia