Activity-based protein profiling guided new target identification of quinazoline derivatives for expediting bactericide discovery
Our research highlights the superiority of ABPP technology, for the first time, identifies the target of engineered quinazolines in pathogenic bacteria, and their potential target fished by ABPP tools holds great promise for the development of quinazoline-based and/or FabF-targeted bactericides.
Authors
- Yue Ding (ORCID: https://orcid.org/0000-0002-7525-1221)
- Xinxin Tuo
- Zhenchao Wang (ORCID: https://orcid.org/0000-0003-1859-0128)
- Jiao Meng (ORCID: https://orcid.org/0000-0001-5081-8490)
- Qing-Su Long
- Xiang Zhou (ORCID: https://orcid.org/0000-0002-3589-9074)
- Kunlun Chen (ORCID: https://orcid.org/0000-0003-1600-1027)
- Mei Li (ORCID: https://orcid.org/0000-0002-1742-2360)
- Song Yang (ORCID: https://orcid.org/0000-0003-1301-3030)
- Ling Zhang (ORCID: https://orcid.org/0000-0001-5397-937X)
- Biao Chen (ORCID: https://orcid.org/0000-0002-2436-4621)
- Guiping Ouyang (ORCID: https://orcid.org/0000-0002-7207-8582)
Institutions
- Guizhou University (CN)
- Guizhou Minzu University (CN)
- Green Chemistry (PL)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1016/j.jare.2024.10.002
- Citations
- 14
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 6.42
Funders
- National Natural Science Foundation of China
- Guizhou University
- National Key Research and Development Program of China