NHC‐Catalyzed [3+3] Cycloaddition of 2‐(acetoxymethyl)buta‐2,3‐dienoates with 1 C,3O‐bisnucleophiles
Abstract Diverse transformations of allenoates catalyzed by Lewis bases have emerged as a powerful platform for generating new chemical entities in organic synthesis. Herein, an N ‐heterocyclic carbene (NHC) catalyzed [3+3] cyclization of 2‐(acetoxymethyl)buta‐2,3‐dienoates with 1 C,3O‐bisnucleophiles has been developed. This approach provides a facile method to synthesize highly functionalized 4 H ‐pyran derivatives with a broad substrate scope (31 examples, up to 83 % yield).
Authors
- Changsheng Yao (ORCID: https://orcid.org/0000-0002-0185-2366)
- Wei Cao (ORCID: https://orcid.org/0000-0001-9615-3754)
- Kai Zhang (ORCID: https://orcid.org/0000-0001-9341-0444)
- Chenxia Yu
Institutions
- Jiangsu Normal University (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1002/ajoc.202400439
- Citations
- 5
- Primary Topic
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province