Predicting Response to Intravesical BCG in High-Risk NMIBC Using an Artificial Intelligence–Powered Pathology Assay: Development and Validation in an International 12-Center Cohort
We developed and validated AI-based histologic assays that identify high-risk nonmuscle-invasive bladder cancer cases at higher risk of recurrence, progression, BCG-unresponsive disease, and cystectomy, potentially aiding clinical decision making.
Authors
- Siddhant Shingi
- Michael A. O’Donnell (ORCID: https://orcid.org/0000-0001-7202-6427)
- Steven Joniau (ORCID: https://orcid.org/0000-0003-3195-9890)
- Andrew Redfern (ORCID: https://orcid.org/0000-0001-6728-8713)
- John Arthur Taylor (ORCID: https://orcid.org/0000-0002-1780-3788)
- Lisa Spalding (ORCID: https://orcid.org/0000-0002-3885-9625)
- Mario I. Fernández (ORCID: https://orcid.org/0000-0001-6424-4977)
- Vrishab Krishna
- Thomas Gerald (ORCID: https://orcid.org/0000-0002-8877-6799)
- L. Baekelandt (ORCID: https://orcid.org/0000-0002-8962-9395)
- Eduardo Eyzaguirre
- Dickon Hayne (ORCID: https://orcid.org/0000-0002-4094-401X)
- Tahlita C.M. Zuiverloon
- Ashish M. Kamat (ORCID: https://orcid.org/0000-0003-3546-9928)
- Bryn Launer (ORCID: https://orcid.org/0000-0002-3802-8709)
- Patrick Joseph Hensley (ORCID: https://orcid.org/0000-0002-8098-901X)
- Yair Lotan (ORCID: https://orcid.org/0000-0001-5692-2723)
- Derek B. Allison (ORCID: https://orcid.org/0000-0002-5119-2474)
- Viswesh Krishna (ORCID: https://orcid.org/0000-0002-2469-2713)
- Vivek Nimgaonkar
- Damir Vrabac
- Jay B. Shah (ORCID: https://orcid.org/0000-0003-1139-8774)
- Roger Li (ORCID: https://orcid.org/0000-0003-1274-7200)
- Eugene Shkolyar (ORCID: https://orcid.org/0000-0002-5410-6412)
- Jennifer Gordetsky (ORCID: https://orcid.org/0000-0002-0745-2160)
- Drew Watson (ORCID: https://orcid.org/0000-0003-4329-7003)
- Vikram M. Narayan (ORCID: https://orcid.org/0000-0003-3731-4209)
- Waleed M. Abuzeid (ORCID: https://orcid.org/0000-0003-2489-0514)
- Marcela Schultz
- Courtney Stewart
- Solomon L. Woldu (ORCID: https://orcid.org/0000-0003-3282-7670)
- Ameer Hamza (ORCID: https://orcid.org/0000-0001-6158-4861)
- Vignesh T. Packiam (ORCID: https://orcid.org/0000-0001-8397-7797)
- Stephen B. Williams
- Snehal Sonawane (ORCID: https://orcid.org/0000-0003-3384-7702)
- Daniel L. Miller (ORCID: https://orcid.org/0000-0002-2104-4614)
- Sam S. Chang (ORCID: https://orcid.org/0000-0003-2066-9468)
- Anirudh Joshi
- Shamsunnahar Imtiaz
Institutions
- University of Iowa (US)
- Universidad del Desarrollo (CL)
- The University of Texas MD Anderson Cancer Center (US)
- University of Kentucky (US)
- Emory University (US)
- The University of Western Australia (AU)
- Universitair Ziekenhuis Leuven (BE)
- Clínica Alemana (CL)
- Erasmus MC (NL)
- Moffitt Cancer Center (US)
- University of Kansas Medical Center (US)
- Stanford Medicine (US)
- The University of Texas Medical Branch at Galveston (US)
- The University of Texas Southwestern Medical Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- The Journal of Urology
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1097/ju.0000000000004278
- Citations
- 3
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Emory University
- Cleveland Clinic
- Dartmouth College