A multimodal characterization of cardiopulmonary resuscitation-associated lung edema
In this porcine model of cardiac arrest followed by a 25-min interval of CPR with mechanical and manual CC, CRALE was consistently present and was characterized by lung inhomogeneity with alveolar tissue and hemorrhage replacing alveolar airspace. Despite mechanical CPR is associated with a more severe CRALE, the higher cardiac output generated by the mechanical compression ultimately accounted for a greater oxygen delivery. Whether specific ventilation strategies might prevent CRALE while preserving hemodynamics remains to be proved.
Authors
- Emanuele Rezoagli (ORCID: https://orcid.org/0000-0002-4506-7212)
- Giacomo Bellani (ORCID: https://orcid.org/0000-0002-3089-205X)
- Aurora Magliocca (ORCID: https://orcid.org/0000-0002-3908-3857)
- D. De Zani (ORCID: https://orcid.org/0000-0002-7032-2297)
- Valentina Castagna
- Antonio Boccardo (ORCID: https://orcid.org/0000-0003-0051-6990)
- Francesca Fumagalli (ORCID: https://orcid.org/0000-0002-9749-4478)
- Giulia Merigo (ORCID: https://orcid.org/0000-0001-9988-2645)
- Davide Danilo Zani (ORCID: https://orcid.org/0000-0002-0444-2784)
- Giuseppe Ristagno (ORCID: https://orcid.org/0000-0002-9235-4820)
- D. Pravettoni (ORCID: https://orcid.org/0000-0003-3338-6053)
- Giacomo Grasselli (ORCID: https://orcid.org/0000-0002-1735-1400)
- Vanessa Zambelli (ORCID: https://orcid.org/0000-0001-8002-5205)
- Jean‐Christophe Richard (ORCID: https://orcid.org/0000-0003-1503-3035)
- Daria De Giorgio (ORCID: https://orcid.org/0000-0002-9704-1524)
Institutions
- University of Milan (IT)
- University of Trento (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- Air Liquide (United Kingdom) (GB)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale Santa Chiara (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Air Liquide (France) (FR)
- Ospedale San Giuseppe (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Université d'Angers (FR)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1186/s40635-024-00680-1
- Citations
- 8
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 5.53
Funders
- Università degli Studi di Milano
- Ministero della Salute
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico