Impact of Respiratory Syncytial Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Coinfection on Clinical Severity and Outcomes Among Children Hospitalized With Lower Respiratory Tract Infections in Soweto, South Africa
Although both RSV and SARS-CoV-2 LRTI occurred commonly, coinfection did not. Children with RSV/SARS-CoV-2 coinfection had a higher prevalence of severe LRTI than those with RSV or SARS-CoV-2-only. These findings reinforce the urgent need for safe and effective RSV and SARS-CoV-2 vaccines, especially in children in low- and middle-income countries, where the burden of disease is the highest and the access to medical resources the lowest.
Authors
- Marta Coelho Nunes (ORCID: https://orcid.org/0000-0003-3788-878X)
- Alane Izu (ORCID: https://orcid.org/0000-0002-5547-7223)
- Kitso-Lesedi Mrubata
- Musawenkosi Ncube (ORCID: https://orcid.org/0000-0003-3124-7033)
- Charl Verwey (ORCID: https://orcid.org/0000-0002-1756-7068)
- Shabir Ahmed Madhi (ORCID: https://orcid.org/0000-0002-7629-0636)
- Ziyaad Dangor (ORCID: https://orcid.org/0000-0003-4089-147X)
- David P. Moore (ORCID: https://orcid.org/0000-0001-6091-1605)
- Vicky Bailie
- Fatima Solomon
Institutions
- Université Claude Bernard Lyon 1 (FR)
- South African Medical Research Council (ZA)
- University of the Witwatersrand (ZA)
- Hospices Civils de Lyon (FR)
- Centre International de Recherche en Infectiologie (FR)
- National Research Foundation (ZA)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1097/inf.0000000000004560
- Citations
- 2
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Bill and Melinda Gates Foundation