Molecular epidemiological analysis of blaNDM-5-producing Klebsiella pneumoniae ST2407-K25 causing infection outbreaks in pediatric patients based on whole genome sequencing
Our study provides evidence of the clonal spread of bla<sub>NDM-5</sub>-producing K. pneumoniae in pediatric patients and the necessity for the T4SS system for horizontal transfer of the IncX3 plasmid carrying bla<sub>NDM-5</sub>. Additionally, the disruption of oqxR may have affected the serum resistance of CRKP. The results of this study emphasize the importance of continuously monitoring for CRKP infection in pediatric patients to prevent recurrent infections.
Authors
- Jingchen Hao
- Jinglan Guo (ORCID: https://orcid.org/0000-0001-8148-7620)
- Zhangrui Zeng (ORCID: https://orcid.org/0000-0001-9099-8342)
- Miran Tang
- Xue Xiao
- Yinhuan Ding (ORCID: https://orcid.org/0000-0002-8002-7056)
- Caihong Ye (ORCID: https://orcid.org/0009-0009-5808-8897)
- Chunxia Jian
- Jinbo Liu
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Annals of Clinical Microbiology and Antimicrobials
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1186/s12941-024-00747-7
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- Southwest Medical University