Infant-derived human nasal organoids exhibit relatively increased susceptibility, epithelial responses, and cytotoxicity during RSV infection
Our data highlights substantial differences in how infant and adult upper respiratory tract epithelium responds to RSV infection at the cellular level. These differences in epithelial cellular response can lead to impaired mucociliary clearance, a more dysregulated innate immune response predisposing infants to more severe RSV infection compared to adults.
Authors
- Gina M. Aloisio (ORCID: https://orcid.org/0000-0003-0710-5094)
- Fabio Stossi (ORCID: https://orcid.org/0000-0001-6029-5478)
- Anubama Rajan (ORCID: https://orcid.org/0000-0003-4773-4362)
- Amal Kambal
- Letisha Aideyan (ORCID: https://orcid.org/0000-0003-0490-4886)
- Divya Narayanan (ORCID: https://orcid.org/0000-0001-9916-0685)
- Pedro A. Piedra (ORCID: https://orcid.org/0000-0002-5839-0879)
- Emily M. Schultz (ORCID: https://orcid.org/0000-0002-1202-198X)
- T. J. Mcbride (ORCID: https://orcid.org/0000-0002-3411-3797)
- David Henke (ORCID: https://orcid.org/0000-0003-2911-2834)
- Vasanthi Avadhanula (ORCID: https://orcid.org/0000-0003-4016-7588)
- Erin G. Nicholson (ORCID: https://orcid.org/0000-0001-9053-9429)
- Sarah Elizabeth Blutt (ORCID: https://orcid.org/0000-0002-4062-709X)
- Laura Ferlic‐Stark (ORCID: https://orcid.org/0000-0003-4860-843X)
- Elina Mosa (ORCID: https://orcid.org/0009-0008-4112-4719)
- Hannah L. Johnson (ORCID: https://orcid.org/0000-0002-6486-7426)
- Ashley M. Murray (ORCID: https://orcid.org/0000-0001-9256-8071)
Institutions
- Baylor College of Medicine (US)
Publication Details
- Journal
- Journal of Infection
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1016/j.jinf.2024.106305
- Citations
- 20
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 7.73
Funders
- Cancer Prevention and Research Institute of Texas
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases