The therapeutic use of clonal neural stem cells in experimental Parkinson´s disease
In this proof-of-concept study, the transplantation of hVM1 clone 32 cells provided neuroprotection in adult Parkinsonian mice by restoring the dopaminergic nigrostriatal pathway and hippocampal neurogenesis, demonstrating the efficacy of cell replacement therapy as a treatment for PD.
Authors
- Anna Nelke (ORCID: https://orcid.org/0000-0001-7281-5944)
- Javier R. Caso (ORCID: https://orcid.org/0000-0001-8622-749X)
- Silvia García‐López
- Marta P. Pereira (ORCID: https://orcid.org/0000-0002-9347-957X)
Institutions
- Universidad Complutense de Madrid (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Centro de Biología Molecular Severo Ochoa (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1186/s13287-024-03965-0
- Citations
- 2
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.82
Funders
- Centro de Biología Molecular Severo Ochoa
- Ministerio de Economía y Competitividad
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III