Palladium-Catalyzed Cyclization and Direct Arylation of 1-[2-(2,2-Dibromoethenyl)phenyl]-1<i>H</i>-pyrrole with Allenes
A novel and efficient palladium-catalyzed highly regioselective reaction of 1-[2-(2,2-dibromoethenyl)phenyl]-1<i>H</i>-pyrrole with allenes was realized to synthesize pyrrolo[1,2-<i>a</i>]quinolones. The tandem process involves intermolecular cyclization and intramolecular direct arylation, leading to the formation three new C-C bonds and two new rings. Notably, this transformation exhibits broad substrate scope and high functional group tolerance.
Authors
- Ping‐Xin Zhou
- Xinqiang Tan (ORCID: https://orcid.org/0000-0003-2200-9340)
- Ying‐Ying Kong (ORCID: https://orcid.org/0000-0001-5027-0787)
- Zicheng Wang (ORCID: https://orcid.org/0000-0002-8105-6908)
- Xu Liu
- Yu-Ji Wu
- Meng-Yue Chen
- Wang Feng
- Shuai Wang (ORCID: https://orcid.org/0009-0002-7506-5426)
- Yong‐Min Liang (ORCID: https://orcid.org/0000-0001-8280-8211)
Institutions
- Lanzhou University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1021/acs.joc.4c00971
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- Natural Science Foundation of Henan Province
- Henan Provincial Science and Technology Research Project