Metabolomic analysis reveals potential role of immunometabolism dysregulation in recurrent pregnancy loss
The study highlights the role of amino acid metabolism in RPL pathogenesis, suggesting that PPA and 5-HTP may be potential predictive indicators, while cystine and tyrosine may potentially regulate immune responses related to RPL. Further investigation into the molecular mechanisms underlying these findings could potentially result in the creation of novel diagnostic and therapeutic approaches for RPL.
Authors
- Yan Guo (ORCID: https://orcid.org/0000-0003-1282-5344)
- Xiaofeng Ye (ORCID: https://orcid.org/0000-0001-9307-636X)
- Zhi Xie (ORCID: https://orcid.org/0000-0002-5589-4836)
- Yanjun Hong (ORCID: https://orcid.org/0000-0003-3059-8130)
- Qingyu Hu (ORCID: https://orcid.org/0000-0001-6799-2217)
- Dongdong Li (ORCID: https://orcid.org/0000-0002-1880-8054)
- Liping Wang (ORCID: https://orcid.org/0000-0001-9477-715X)
- Wenqi Guo
- Chong Ma (ORCID: https://orcid.org/0000-0002-5054-9259)
- Sihang Zhou
Institutions
- Sun Yat-sen University (CN)
- Guangxi University of Chinese Medicine (CN)
- Shenzhen University Health Science Center (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-10-09
- DOI
- https://doi.org/10.3389/fendo.2024.1476774
- Citations
- 6
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 1.44
Funders
- National Natural Science Foundation of China
- Shenzhen University