Characterization of monoclonal antibody charge variants under near-native separation conditions using nanoflow sheath liquid capillary electrophoresis-mass spectrometry
This manuscript describes a new CZE-MS method that permits heterogeneity assessment of mAbs under MS-compatible conditions, providing charge variant separation.
Authors
- Tijmen S. Bos (ORCID: https://orcid.org/0000-0002-0728-6385)
- Rob Haselberg (ORCID: https://orcid.org/0000-0003-1892-1724)
- Alisa Höchsmann (ORCID: https://orcid.org/0009-0006-3724-9792)
- Andrea Gargano (ORCID: https://orcid.org/0000-0003-3361-7341)
- Kevin Jooß (ORCID: https://orcid.org/0000-0003-1669-7837)
- Govert W. Somsen (ORCID: https://orcid.org/0000-0003-4200-2015)
- Christian Neusüß (ORCID: https://orcid.org/0000-0003-2404-4924)
- Annika A. M. van der Zon (ORCID: https://orcid.org/0009-0001-9113-3014)
Institutions
- Hochschule Aalen (DE)
- Amsterdam University of Applied Sciences (NL)
- University of Tübingen (DE)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Analytica Chimica Acta
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1016/j.aca.2024.343287
- Citations
- 5
- Primary Topic
- Protein purification and stability
- Type
- article
- Field-Weighted Citation Impact
- 1.17