Morinda officinalis iridoid glycosides, as an inhibitor of GSK-3β, alleviates rheumatoid arthritis through inhibition of NF-κB and JAK2/STAT3 pathway
MOIG alleviates joint inflammation in RA through inhibition NF-κB and JAK2/STAT3 pathway via suppression of GSK-3β in FLSs, which provides supports for MOIG as a promising therapeutic agent of RA.
Authors
- Luping Qin (ORCID: https://orcid.org/0000-0002-5056-6497)
- Quanlong Zhang (ORCID: https://orcid.org/0000-0002-1680-4869)
- Yi Shen (ORCID: https://orcid.org/0000-0001-5072-4734)
- Xinyuan Ye
- Qiuru Ren
- Ting Han (ORCID: https://orcid.org/0000-0003-4365-0479)
- Yiqi Sun
- Qiming Zhao (ORCID: https://orcid.org/0000-0001-6173-9595)
- Ronghua Bao
- Jinman Du
- Tianwen Ye
- Qiaoyan Zhang (ORCID: https://orcid.org/0000-0003-3959-1103)
- Heming Li (ORCID: https://orcid.org/0000-0002-5702-0147)
Institutions
- Zhejiang Chinese Medical University (CN)
- Shanghai Changzheng Hospital (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-09
- DOI
- https://doi.org/10.3389/fphar.2024.1435274
- Citations
- 3
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- National Natural Science Foundation of China
- Zhejiang Chinese Medical University
- Natural Science Foundation of Zhejiang Province