Plasma metabolome mediates the causal relationship between immune cells and heart failure: a two-step bidirectional Mendelian randomization study
This study provides evidence that certain immune cell levels are associated with the risk of HF and that metabolite levels may mediate these relationships. However, to strengthen these findings, further validation using MR analyses with larger sample sizes is essential.
Authors
- Zhongyong Liu
- Tan Li (ORCID: https://orcid.org/0000-0001-8975-2847)
- Yanwei Liu (ORCID: https://orcid.org/0009-0002-3464-5512)
- Langlang Huang
- Juncong Fu
Institutions
- Shangrao Normal University (CN)
- Jiangxi University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2024-10-09
- DOI
- https://doi.org/10.3389/fcvm.2024.1430477
- Citations
- 2
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Health Commission of Jiangxi Province