The NEDD4/FLRT2 axis regulates NSCLC cell stemness
This study revealed that FLRT2 acted as a tumor suppressor by inhibiting cancer cell stemness in NSCLC. NEDD4 promoted ubiquitination degradation of FLRT2 protein. NEDD4 counteracted the inhibitory effects of FLRT2 on NSCLC stem cell tumorigenesis.
Authors
- Wei Zhao (ORCID: https://orcid.org/0000-0003-2421-7311)
- Na Huang (ORCID: https://orcid.org/0000-0001-5799-1894)
- Ziwei Gao (ORCID: https://orcid.org/0000-0002-2547-9375)
- Qi Li (ORCID: https://orcid.org/0000-0001-7786-6839)
- Jiayuan Li (ORCID: https://orcid.org/0000-0003-0063-0195)
- Fei Yan (ORCID: https://orcid.org/0000-0002-1923-2093)
- Yuping Yang (ORCID: https://orcid.org/0000-0002-2226-7676)
- Shengke Wen
- Houke Li
Institutions
- Chengdu Medical College (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
- Jiangsu Cancer Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-09
- DOI
- https://doi.org/10.3389/fphar.2024.1459978
- Citations
- 2
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Chengdu Medical College