Vitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryos
HFHS-fed SR-B1 HET females exhibited altered glucose metabolism and excess circulating lipids, along with a higher incidence of embryos with developmental delay and NTD. Vitamin E supplementation partially mitigated HFHS-induced maternal metabolic abnormalities and completely prevented embryonic malformations, likely through indirect mechanisms involving the reduction of oxidative stress and improved lipid handling by the parietal yolk sac.
Authors
- Fujiko Saavedra
- Dolores Busso (ORCID: https://orcid.org/0000-0003-2113-1926)
- Alonso Quíroz
- Gabriela Belledonne
- Javier González
Institutions
- Pontificia Universidad Católica de Chile (CL)
- Universidad de Los Andes, Chile (CL)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2024-10-09
- DOI
- https://doi.org/10.3389/fcell.2024.1460697
- Citations
- 1
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Massachusetts Institute of Technology
- Pontificia Universidad Católica de Chile
- Agencia Nacional de Investigación y Desarrollo
- Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica