Fentanyl enhances immune cell response through TLR4/MD-2 complex
These results provide new insight into the mechanism of the proinflammatory activity of fentanyl, which involves the activation of TLR4/MD-2 signaling. Our findings might facilitate the development of novel inhibitors of TLR4/MD-2 signaling to combine with opioid-based analgesics for effective and safe pain management.
Authors
- Pietro Giusti (ORCID: https://orcid.org/0000-0001-9352-4046)
- Morena Zusso (ORCID: https://orcid.org/0000-0002-6577-2947)
- Chiara Bolego (ORCID: https://orcid.org/0000-0003-4006-0203)
- Massimo Barbierato
- Giovanni Eugenio Ramaschi
- Laura Facci
- Chiara Chemello
- Emma Marcolin
Institutions
- University of Padua (IT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-09
- DOI
- https://doi.org/10.3389/fphar.2024.1468644
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.48