The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity

GAS5 appears to modulate NF-κB activity in a complex manner, influencing both basal and GC-induced signaling. The interaction between GAS5, GCs, and NF-κB is multi-faceted, and further research is needed to fully elucidate the underlying mechanisms. These findings suggest that GAS5 could be a potential target for personalized therapy, particularly in pediatric patients with inflammatory conditions.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2024-10-09
DOI
https://doi.org/10.3389/fphar.2024.1448136
Citations
3
Primary Topic
Cancer-related molecular mechanisms research
Type
article
Field-Weighted Citation Impact
0.86

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article

The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity

Biljana Stanković, Debora Curci, Letizia Pugnetti, Sonja Pavlović et al.
3 citations
Frontiers in Pharmacology
Cancer-related molecular mechanisms research
0.86
article

The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity

Biljana Stanković, Debora Curci, Letizia Pugnetti, Sonja Pavlović, Gabriele Stocco, Branka Zukić, Vladimir Gašić, Nikola Kotur, Maurizio Romano, Marianna Lucafò, Giuliana Decorti
article en
3 citations

Abstract

GAS5 appears to modulate NF-κB activity in a complex manner, influencing both basal and GC-induced signaling. The interaction between GAS5, GCs, and NF-κB is multi-faceted, and further research is needed to fully elucidate the underlying mechanisms. These findings suggest that GAS5 could be a potential target for personalized therapy, particularly in pediatric patients with inflammatory conditions.

Frontiers in PharmacologyVol. 15
University of Trieste (IT), IRCCS Materno Infantile Burlo Garofolo (IT), University of Belgrade (RS)
Ministero della Salute
Good health and well-being
Openalex Percentile: Top 25%
Cancer-related molecular mechanisms research
0.86
DOIOpen Access PDFOpenAlex
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The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity — Biljana Stanković, Debora Curci, et al. · Frontiers in Pharmacology (2024) | TGRS Research Map | TGRS