Induction of cytochrome P450 via upregulation of CAR and PXR: a potential mechanism for altered florfenicol metabolism by macranthoidin B in vivo
These findings suggest that MB-induced alterations in florfenicol pharmacokinetics, particularly its accelerated elimination, may be due to increased expression and activities of CYP1A2 and CYP2C11, with CAR and PXR potentially involved in these regulatory effects. Further investigation is yet needed to fully elucidate the clinical implications of these interactions concerning the efficacy of florfenicol in veterinary medicine.
Authors
- Bin Wang (ORCID: https://orcid.org/0000-0003-1500-1543)
- Ziyi Yang (ORCID: https://orcid.org/0000-0001-5883-9552)
- Min Zhang (ORCID: https://orcid.org/0000-0001-9794-4523)
- Liang Ge (ORCID: https://orcid.org/0000-0002-2945-3287)
- Sicong Li (ORCID: https://orcid.org/0000-0003-1111-3580)
- Xuting Li (ORCID: https://orcid.org/0000-0002-5129-3363)
- Qin Yin (ORCID: https://orcid.org/0000-0001-8477-1117)
Institutions
- Sichuan Animal Science Academy (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-09
- DOI
- https://doi.org/10.3389/fphar.2024.1460948
- Citations
- 1
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- China Agricultural Research System
- Serbian Academy of Sciences and Arts
- Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System