Impacts on study design when implementing digital measures in Parkinson's disease-modifying therapy trials
Overall, at-home measures have a favorable reliability profile for sensitive detection of treatment effects in DMT trials. Future work is needed to better understand the causes of variability in PD progression and identify the most appropriate statistical methods for effect detection.
Authors
- Jessie P. Bakker (ORCID: https://orcid.org/0000-0002-2976-4747)
- Elena S. Izmailova (ORCID: https://orcid.org/0000-0002-7150-1748)
- Seth Haney (ORCID: https://orcid.org/0000-0002-4763-3548)
- Larsson Omberg (ORCID: https://orcid.org/0000-0002-4719-9120)
- Anthony D. Scotina (ORCID: https://orcid.org/0000-0003-1301-3209)
- Jennie S. Lavine (ORCID: https://orcid.org/0000-0003-1793-5497)
Publication Details
- Journal
- Frontiers in Digital Health
- Published
- 2024-10-09
- DOI
- https://doi.org/10.3389/fdgth.2024.1430994
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.11