Periodontal ligament stem cell tissue engineering scaffolds can guide and promote canine periodontal tissue regeneration

The canine PDLSC tissue engineering scaffold was transplanted into the single wall bone defect of the first mandibular molar tooth of the dog without causing inflammatory reactions, and the tissue compatibility was satisfactory. The cell-scaffold complex can increase the content of related growth factors and immunomodulatory factors in the tissues, reduce the content of proinflammatory factors, and prevent the growth of binding epithelium in the defect area, thus forming new bone and new periodontal ligaments in the defect area, promoting the repair of periodontal defects, and improving the therapeutic effect of guided regeneration.