Identification of porcine PARP11 as a restricted factor for pseudorabies virus
In this study, we identified PARP11 as a host factor that can significantly affect PRV infection. Inhibition of PARP11 and knockout of PARP11 can significantly promoted PRV infection. Subsequently, we further found that PARP11 knockout upregulated the transcription of NXF1 and CRM1, resulting in enhanced transcription of viral genes. Furthermore, we also found that PARP11 knockout could activate the autophagy pathway and suppress the mTOR pathway during PRV infection. These findings could provide insight into the mechanism in which PARP11 participated during PRV infection and offer a potential target to develop anti-PRV therapies.
Authors
- Chunyun Qi
- Shuyu Zhong
- Jian Zhou (ORCID: https://orcid.org/0000-0002-9464-8857)
- Dongmei Lv (ORCID: https://orcid.org/0000-0002-7490-9773)
- Heyong Wu
- Hongming Yuan (ORCID: https://orcid.org/0000-0002-0809-5599)
- Daxin Pang (ORCID: https://orcid.org/0000-0001-5070-125X)
- Hongsheng Ouyang (ORCID: https://orcid.org/0000-0001-7661-295X)
- Li Feng (ORCID: https://orcid.org/0000-0003-4123-0892)
- Tianyi Zhang (ORCID: https://orcid.org/0000-0002-2833-3363)
- Xi Wang (ORCID: https://orcid.org/0009-0004-9115-8539)
- Zicong Xie (ORCID: https://orcid.org/0000-0002-3354-1618)
- Lanxin Hu (ORCID: https://orcid.org/0000-0002-3658-4859)
- Dehua Zhao (ORCID: https://orcid.org/0000-0001-6303-4601)
- Yuran Huo
- Shouqing Yan
- A QI
- Qiuse Tu
- Yao Wang (ORCID: https://orcid.org/0000-0002-1690-0738)
Institutions
- Jilin University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-10-09
- DOI
- https://doi.org/10.3389/fcimb.2024.1414827
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00