Cannabiorcol as a novel inhibitor of the p38/MSK-1/NF-κB signaling pathway, reducing matrix metalloproteinases in osteoarthritis
Cannabiorcol inhibits IL-1β-induced MMP expression in vitro and alleviates OA in an MIA-induced OA rat model by reducing MMP expression and inhibiting the p65/p38 axis.
Authors
- Youngsic Jeon (ORCID: https://orcid.org/0000-0002-5673-5036)
- Jungyeob Ham (ORCID: https://orcid.org/0000-0003-3046-9267)
- Hyukjoon Kwon
- Young Joo Yeon (ORCID: https://orcid.org/0000-0003-1400-8014)
- Young‐Joo Kim (ORCID: https://orcid.org/0000-0003-1080-0581)
- Taejung Kim (ORCID: https://orcid.org/0000-0002-9449-4763)
- Jiyool Kim (ORCID: https://orcid.org/0000-0001-6724-6118)
Institutions
- Gangneung–Wonju National University (KR)
- Korea Institute of Science and Technology (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1016/j.phymed.2024.156141
- Citations
- 6
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.82
Funders
- Ministry of Food and Drug Safety
- Korea Institute of Science and Technology
- National Research Foundation of Korea
- Ministry of SMEs and Startups
- Ministry of Science and ICT, South Korea