Distinct virologic trajectories in chronic hepatitis B identify heterogeneity in response to nucleos(t)ide analogue therapy
Treatment recommendations for people living with chronic hepatitis B virus (HBV) infection are becoming less stringent, meaning that more of the population will be eligible to receive therapy with nucleos(t)ide analogue agents. We explored outcomes of HBV treatment in a large UK dataset, describing different responses to treatment, and showing that the viral load is not completely suppressed after 1 year in about one in five cases, associated with an increased risk of liver complications. As treatment is rolled out more widely, patients and clinicians need to be aware of the potential for incomplete virologic responses. The findings can support the identification of high-risk individuals, improve early fibrosis and cirrhosis prediction, guide monitoring and preventive interventions, and support public health elimination goals.
Authors
- Alexander J. Stockdale (ORCID: https://orcid.org/0000-0002-5828-3328)
- Erik Mayer (ORCID: https://orcid.org/0000-0002-5509-4580)
- Stephen Ryder (ORCID: https://orcid.org/0000-0001-9649-4444)
- Juliette Verheyden
- Gail Roadknight (ORCID: https://orcid.org/0000-0002-1158-0181)
- Kinga A. Várnai (ORCID: https://orcid.org/0000-0001-5695-9497)
- William Gelson (ORCID: https://orcid.org/0000-0002-8100-8703)
- Ben Glampson (ORCID: https://orcid.org/0000-0002-5601-5581)
- Finola Higgins
- Luca Mercuri (ORCID: https://orcid.org/0000-0001-9076-5717)
- Stephanie Little (ORCID: https://orcid.org/0000-0002-2954-8649)
- J Jaworski (ORCID: https://orcid.org/0009-0007-0651-3439)
- Salim I. Khakoo (ORCID: https://orcid.org/0000-0002-4057-9091)
- Suzanne Maynard (ORCID: https://orcid.org/0000-0003-3039-2562)
- Sarah Montague (ORCID: https://orcid.org/0000-0002-1988-7364)
- Irene Juurlink
- William E. Bernal (ORCID: https://orcid.org/0000-0002-6508-3287)
- Michael George (ORCID: https://orcid.org/0000-0003-4452-8328)
- Louise English (ORCID: https://orcid.org/0009-0004-0193-4355)
- Hizni Salih (ORCID: https://orcid.org/0000-0002-5283-7799)
- Lara N. Roberts (ORCID: https://orcid.org/0000-0003-3871-8491)
- Timothy K. Roberts (ORCID: https://orcid.org/0000-0002-6680-4816)
- Yun Kim (ORCID: https://orcid.org/0000-0002-9809-7351)
- Karl McIntyre
- Theresa Noble (ORCID: https://orcid.org/0000-0002-4984-2538)
- Ruth Norris
- Ashley Heinson (ORCID: https://orcid.org/0000-0001-8695-6203)
- Andrew Frankland (ORCID: https://orcid.org/0000-0001-9552-0890)
- Kathryn Jack (ORCID: https://orcid.org/0000-0002-8596-4073)
- Philippa Clare Matthews (ORCID: https://orcid.org/0000-0002-4036-4269)
- Luis Romão (ORCID: https://orcid.org/0000-0001-5545-5289)
- Lauren Poole
- Christopher R. Jones (ORCID: https://orcid.org/0000-0002-6301-2282)
- Ahmed Mohamed Elsharkawy (ORCID: https://orcid.org/0000-0001-5369-3734)
- Florina Borca (ORCID: https://orcid.org/0000-0003-0596-7352)
- Shazaad Ahmad (ORCID: https://orcid.org/0000-0002-0400-8937)
- George Tilston (ORCID: https://orcid.org/0000-0003-1475-5888)
- David Ramlakhan
- Tingyan Wang (ORCID: https://orcid.org/0000-0002-8351-9494)
- Cori Campbell (ORCID: https://orcid.org/0000-0001-5890-7105)
- Stacy Todd (ORCID: https://orcid.org/0000-0003-3215-9625)
- Nicholas Easom (ORCID: https://orcid.org/0000-0001-6413-919X)
- Cai Davis (ORCID: https://orcid.org/0000-0003-3710-1879)
- J. O. Meneses
- Victoria Day
- Javier Vilar
- Simon Stanworth
- Douglas MacDonald
- Heather Rogers
- Dimitri Papadimitriou (ORCID: https://orcid.org/0000-0002-7495-3221)
- Heidi MacNaughton
- Ilina Serafimova
- Alex Waldren-Glenn
- Berit Reglar
Institutions
- University College Hospital (GB)
- University of Liverpool (GB)
- Imperial College Healthcare NHS Trust (GB)
- The Francis Crick Institute (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Royal Liverpool University Hospital (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- University of Oxford (GB)
- NIHR Imperial Biomedical Research Centre (GB)
- UCL Biomedical Research Centre (GB)
- Oxford BioMedica (United Kingdom) (GB)
- University of Southampton (GB)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101229
- Citations
- 7
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- GlaxoSmithKline
- Roche
- Wellcome Trust
- Francis Crick Institute
- National Institute for Health and Care Research
- University of Liverpool
- National Institute for Health Research Southampton Biomedical Research Centre
- UCLH Biomedical Research Centre
- University College London Hospitals Biomedical Research Centre
- NIHR Imperial Biomedical Research Centre
- NIHR Oxford Biomedical Research Centre
- NIHR Cambridge Biomedical Research Centre
- NIHR Great Ormond Street Hospital Biomedical Research Centre