Reaction of acetylenic carbanions with C=N bond: dynamics of development, synthetic divergence, environmental safety

This review highlights the dynamics of the development and synthetic application of the recently discovered reaction of acetylenic carbanions, generated in superbase media, with the C=N bond of different classes of substrates. A fundamental feature of this reaction is its synthetic divergence,<i> i.e.</i> its ability to proceed in different directions, which manifests itself in novel transformations to selectively deliver structurally different synthetically important products (depending on the structure of the acetylenes and substrates with C=N bond). The review also discusses cascade processes, in which the key intermediates containing the C=N bond add acetylenes thereby participating in the self-organization of diverse and potentially useful compounds. The competitive advantage of the reaction and its daughter branches is environmental safety (neutrality), based on the fundamental chemical nature of these reactions as addition processes that occur without the release of by-products.<br> The bibliography includes 133 references.