Generation of patient-derived induced pluripotent stem cell line UJSi004-A from ultra-treatment-resistant schizophrenia
Schizophrenia is a severe mental illness with disabling effects. Induced pluripotent stem cells (iPSCs) are generated by reprogramming peripheral blood mononuclear cells (PBMCs) from patients with ultra-treatment-resistant schizophrenia (UTRS). iPSCs have normal karyotype, express pluripotency markers and differentiate into three germ layers in vivo. This iPSC cell line carries the genetic information of the patient and is a good model for studying disease mechanisms and developing new therapies.
Authors
- Bing Xue (ORCID: https://orcid.org/0000-0002-2341-3460)
- Shengying Qin (ORCID: https://orcid.org/0000-0002-8458-5960)
- Tianchi Song
- Siyu Xi
- Yupeng Wang (ORCID: https://orcid.org/0000-0002-9723-7287)
- Jing Sun (ORCID: https://orcid.org/0000-0001-7097-9590)
- Zhenghua Shan
Institutions
- Jiangsu University (CN)
- Nantong University (CN)
- Ministry of Education (TH)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1016/j.scr.2024.103575
- Citations
- 2
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.47