Clinical and genetic spectrum of factor XII deficiency in the Han population of East China
We speculate on the potential impact of recurrent mutations on the efficacy of new drugs being developed to target FXII for thrombosis prevention and treatment. Furthermore, it is important to explore their influence on FXII-related pathways beyond the activation of the contact pathway in the coagulation cascade.
Authors
- Bile Chen
- Lingling Hou (ORCID: https://orcid.org/0000-0002-2111-2998)
- Mingshan Wang (ORCID: https://orcid.org/0000-0003-4663-2735)
- L Qin (ORCID: https://orcid.org/0009-0009-3726-3326)
- Anqing Zou
- Fei Xu (ORCID: https://orcid.org/0009-0000-3433-9596)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1186/s13023-024-03404-6
- Citations
- 2
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.88