Mexican calea (Calea zacatechichi Schltdl.) interferes with cholinergic and dopaminergic pathways and causes neuroglial toxicity
Our findings regarding the neuroglial toxicity elicited by C. zacatechichi emphasize the necessity for a thorough elucidation of the plant's toxicity profile. Additionally, evidence is provided that the aerial parts of the plant inhibit both acetylcholinesterase and tyrosinase, potentially linking its psychopharmacological effects to the cholinergic and dopaminergic systems, with an apparent contribution from specific phenolic constituents previously unknown to occur in the species. Collectively, our results lay the groundwork for a regulatory framework on the consumption of C. zacatechichi in recreational settings and contribute to elucidating previous contradictory findings regarding the mechanisms underlying the dream-inducing effects of the plant.
Authors
- Paula B. Andrade
- Romeu A. Videira (ORCID: https://orcid.org/0000-0002-4170-0092)
- María Rita Concepción García (ORCID: https://orcid.org/0000-0003-0914-1734)
- Diana Dias da Silva (ORCID: https://orcid.org/0000-0002-7331-9157)
- Nelson G. M. Gomes (ORCID: https://orcid.org/0000-0002-8727-9678)
- Federico Ferreres (ORCID: https://orcid.org/0000-0002-8682-0004)
- Ángel Gil‐Izquierdo (ORCID: https://orcid.org/0000-0001-7646-0386)
- Vítor Seabra (ORCID: https://orcid.org/0000-0002-8704-5775)
- Tiago Mineiro
Institutions
- Universidade do Porto (PT)
- Cooperativa de Ensino Superior Politécnico e Universitário (PT)
- Centro de Edafología y Biología Aplicada del Segura (ES)
- Rede de Química e Tecnologia (PT)
- Universidad Católica de Murcia (ES)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1016/j.jep.2024.118915
- Citations
- 3
- Primary Topic
- Biochemical Analysis and Sensing Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.93