Impact of Sleep Quality on Hemogram-Derived Inflammatory Indices in Medical Undergraduates: A Cross-Sectional Study

The link between sleep-related disorders and inflammation is well-known, but the association between inflammatory indices and sleep deprivation is still unclear. In our study, we aimed to investigate the relationship between irregular sleep patterns and systemic inflammation using Hemogram-Based Inflammatory Indices. We collected demographic information from 90 undergraduate medical students through a confidential questionnaire. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Blood samples were obtained for complete blood count analysis, with platelet (P), lymphocyte (L), and neutrophil (N) counts measured. These values were then used to calculate hemogram-based inflammatory indices, including the Systemic Immune-Inflammation Index (SII), Platelet-to-Lymphocyte Ratio (PLR), and Neutrophil-to-Lymphocyte Ratio (NLR). A high prevalence of inconsistent sleep was observed among medical students, with 53% reporting a PSQI score greater than 5(mean score 5.9±2.9). Subjects with poor sleep quality had elevated SII values. Additionally, female participants who experienced poor sleep quality demonstrated a significant positive correlation with SII (r=0.322; p<0.049). Irregular sleep patterns are associated with greater systemic inflammation milieu specifically with SII compared to NLR and PLR. This effect was more pronounced in female participants, suggesting a potential gender-specific influence.