Pre-existing parasympathetic dominance seems to cause persistent heart rate slowing after 6 months of fingolimod treatment in patients with multiple sclerosis
Our patients with prolonged HR slowing upon fingolimod initiation could not downregulate cardiovagal modulation upon standing up even before fingolimod initiation, and 6 months after fingolimod initiation still had more parasympathetic effect on HR while cardiovagal modulation and BRS were attenuated in the other 23 patients. Pre-existing parasympathetic predominance may cause prolonged HR slowing upon fingolimod initiation.
Authors
- Ralf A. Linker (ORCID: https://orcid.org/0000-0001-9775-3719)
- Ruihao Wang (ORCID: https://orcid.org/0000-0003-4792-5572)
- Federico Canavese (ORCID: https://orcid.org/0000-0002-6114-5372)
- Carmen de Rojas-Leal
- Max J. Hilz
- De-Hyung Lee
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University Hospital Regensburg (DE)
- Universitätsklinikum Erlangen (DE)
- Mount Sinai Hospital (US)
- Hospital Clínico Universitario Virgen de la Victoria (ES)
- University of Regensburg (DE)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Clinical Autonomic Research
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1007/s10286-024-01073-w
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitätsklinikum Erlangen
- Novartis Pharma