DNA demethylation triggers cell free DNA release in colorectal cancer cells
Methylation status of cancer cell lines contributes to the variability of cfDNA shedding in vitro. Changes in methylation pattern are associated with cfDNA release levels and might be exploited to increase sensitivity of liquid biopsy assays.
Authors
- Federica Di Nicolantonio (ORCID: https://orcid.org/0000-0001-9618-2010)
- Paolo Battuello
- Marco Viviani (ORCID: https://orcid.org/0000-0003-4698-8870)
- Alessandro Cavaliere (ORCID: https://orcid.org/0000-0002-8690-5382)
- Giovanni Crisafulli (ORCID: https://orcid.org/0000-0002-5511-1555)
- Laura Monteonofrio (ORCID: https://orcid.org/0000-0003-3981-942X)
- Marco Macagno (ORCID: https://orcid.org/0000-0002-1749-7813)
- Silvia Soddu
- Giulia Gionfriddo
- Michèle Milella (ORCID: https://orcid.org/0000-0002-3826-5237)
- Michael Linnebacher (ORCID: https://orcid.org/0000-0001-8054-1402)
- Andrea Bertotti (ORCID: https://orcid.org/0000-0001-8196-7608)
- Ludovic Barault (ORCID: https://orcid.org/0000-0001-5227-5047)
- Noemi Congiusta (ORCID: https://orcid.org/0000-0001-5745-7069)
- Elena Grassi (ORCID: https://orcid.org/0000-0003-1066-927X)
- Luca Cardone (ORCID: https://orcid.org/0000-0001-8184-2856)
- Simonetta Guarrera (ORCID: https://orcid.org/0000-0003-4400-1817)
- Elisa Mariella (ORCID: https://orcid.org/0000-0002-3612-8116)
- Alice Bartolini (ORCID: https://orcid.org/0000-0003-3492-0772)
- Alberto Bardelli (ORCID: https://orcid.org/0000-0003-1647-5070)
- Daniele Oddo (ORCID: https://orcid.org/0000-0001-6179-1668)
- Fariha Idrees
- Annalisa Lorenzato (ORCID: https://orcid.org/0000-0002-9324-2337)
- Valeria Pessei (ORCID: https://orcid.org/0009-0004-1598-5268)
- Simona Lamba (ORCID: https://orcid.org/0000-0003-3207-1594)
- Vittorio Battaglieri
Institutions
- University of Verona (IT)
- IFOM (IT)
- Italian institute for Genomic Medicine (IT)
- Candiolo Cancer Institute (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Turin (IT)
Publication Details
- Journal
- Genome Medicine
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1186/s13073-024-01386-5
- Citations
- 6
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.40