DNA demethylation triggers cell free DNA release in colorectal cancer cells

Methylation status of cancer cell lines contributes to the variability of cfDNA shedding in vitro. Changes in methylation pattern are associated with cfDNA release levels and might be exploited to increase sensitivity of liquid biopsy assays.

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Publication Details

Journal
Genome Medicine
Published
2024-10-09
DOI
https://doi.org/10.1186/s13073-024-01386-5
Citations
6
Primary Topic
Epigenetics and DNA Methylation
Type
article
Field-Weighted Citation Impact
1.40
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article

DNA demethylation triggers cell free DNA release in colorectal cancer cells

Federica Di Nicolantonio, Paolo Battuello, Marco Viviani, Alessandro Cavaliere et al.
6 citations
Genome Medicine
Epigenetics and DNA Methylation
1.40
article

DNA demethylation triggers cell free DNA release in colorectal cancer cells

Federica Di Nicolantonio, Paolo Battuello, Marco Viviani, Alessandro Cavaliere, Giovanni Crisafulli, Laura Monteonofrio, Marco Macagno, Silvia Soddu, Giulia Gionfriddo, Michèle Milella, Michael Linnebacher, Andrea Bertotti, Ludovic Barault, Noemi Congiusta, Elena Grassi, Luca Cardone, Simonetta Guarrera, Elisa Mariella, Alice Bartolini, Alberto Bardelli, Daniele Oddo, Fariha Idrees, Annalisa Lorenzato, Valeria Pessei, Simona Lamba, Vittorio Battaglieri
article en
6 citations

Abstract

Methylation status of cancer cell lines contributes to the variability of cfDNA shedding in vitro. Changes in methylation pattern are associated with cfDNA release levels and might be exploited to increase sensitivity of liquid biopsy assays.

Genome MedicineVol. 16(1)
University of Verona (IT), IFOM (IT), Italian institute for Genomic Medicine (IT), Candiolo Cancer Institute (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), University of Turin (IT)
Good health and well-being
Openalex Percentile: Top 19%
Epigenetics and DNA Methylation
1.40
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