The diagnostic value and validation of IL-22 combined with sCD40L in tuberculosis pleural effusion
We demonstrated that the levels of IL-1β, IL-4, IL-6, IL-10, IL-17 A, IL-17 F, IL-21, IL-22, IL-25, IL-31, IL-33, IFN-γ, sCD40L and TNF-α in pleural effusion had significant difference between tuberculosis pleurisy and malignant pleurisy. Specifically, IL-22 ≥ 18.87 pg/mL and sCD40L ≥ 53.08 pg/mL can be clinically utilized as an efficient diagnostic strategy for distinguishing tuberculosis pleurisy from malignant pleurisy.
Authors
- Qiuju Yao (ORCID: https://orcid.org/0000-0001-9781-186X)
- Yan Gao (ORCID: https://orcid.org/0000-0002-2954-1922)
- Bingyan Zhang (ORCID: https://orcid.org/0000-0001-6613-0914)
- Huaxin Chen (ORCID: https://orcid.org/0000-0002-0018-5872)
- Yuzhen Xu (ORCID: https://orcid.org/0000-0002-1289-3438)
- Sen Wang (ORCID: https://orcid.org/0000-0002-8325-6348)
- Qianqian Liu (ORCID: https://orcid.org/0000-0003-3325-5942)
- Yuanyuan Liu (ORCID: https://orcid.org/0000-0001-6862-1928)
- Wenhong Zhang (ORCID: https://orcid.org/0000-0002-9682-827X)
- Lingyun Shao (ORCID: https://orcid.org/0000-0001-8514-1029)
- Jing Wu
- Qinfang Ou
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Wuxi No.2 People's Hospital (CN)
- PLA Navy General Hospital (CN)
- Wuxi People's Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- BMC Immunology
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1186/s12865-024-00652-w
- Citations
- 1
- Primary Topic
- Pleural and Pulmonary Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality