Anti-inflammatory and antinociceptive effects of Aloysia gratissima leaves essential oil: An in vivo study
The minimum effective dose of OAG in the formalin test was 1 mg/kg. This dose did not affect the locomotor activity of mice. The OAG decreased the number of leukocytes/mm³ in the peritoneal exudate of mice and reduced paw edema 45 min after the arachidonic acid injection. OAG treatment elicited a reduction in NPSH levels in the paw tissue and increased NPSH levels in mice blood plasma and did not cause mice mortality. The OAG is devoid of acute toxicity and shows anti-inflammatory activity, which can be related to the presence of pinocamphone, guaiol, and <i>β-</i>pinene and is mediated, at least in part, by mechanisms that involve the participation of NPSH.
Authors
- Otávio Sanaiotto
- Indiara Brusco (ORCID: https://orcid.org/0000-0003-1816-2924)
- Samara Cristina Mazon (ORCID: https://orcid.org/0000-0002-9197-2811)
- Liz Girardi Müller (ORCID: https://orcid.org/0000-0002-4479-889X)
- J. Vladimir Oliveira (ORCID: https://orcid.org/0000-0002-6196-3498)
- Jacir Dal Magro (ORCID: https://orcid.org/0000-0002-6465-6661)
- Jaqueline Scapinello (ORCID: https://orcid.org/0000-0003-3747-3381)
- Monica Santin Zanatta Schindler (ORCID: https://orcid.org/0000-0001-6710-2229)
- Maryelen Alijar Souza
- Ana C. Provinelli
- Ketelin Kunh
- Mayara Barufke
Institutions
- Universidade do Estado de Santa Catarina (BR)
- Community University of Chapecó Region - Unochapecó (BR)
- Universidade Federal de Santa Catarina (BR)
Publication Details
- Journal
- Journal of Traditional and Complementary Medicine
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1016/j.jtcme.2024.10.002
- Citations
- 2
- Primary Topic
- Essential Oils and Antimicrobial Activity
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Universidade Comunitária da Região de Chapecó
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina