Effect of sequencing platforms on the sensitivity of chemical mutation detection using Hawk-Seq™
All platforms sensitively detected mutagen-induced mutations using the Hawk-Seq™ analysis. The substitution types and frequencies of the background errors differed depending on the platform. The effects of sequencing platforms on mutagenicity evaluation should be assessed before experimentation.
Authors
- Masaaki Miyazawa (ORCID: https://orcid.org/0000-0002-7300-119X)
- Shoji Matsumura (ORCID: https://orcid.org/0000-0002-3864-1132)
- Kei‐ichi Sugiyama
- Kenichi Masumura (ORCID: https://orcid.org/0000-0002-7907-164X)
- Takayoshi Suzuki (ORCID: https://orcid.org/0000-0002-2261-5263)
- Sayaka Hosoi
- Kazutoshi Saito
- Yuki Otsubo
- Takako Hirose
Institutions
- Kao Corporation (Japan) (JP)
- National Institute of Health Sciences (JP)
Publication Details
- Journal
- Genes and Environment
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1186/s41021-024-00313-9
- Citations
- 2
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.57