Changes in bone density and microarchitecture in adolescents undergoing a first kidney transplantation: a prospective study
Bone density and microarchitecture at the time of KTx were superior compared to HC, but radial trabecular bone microarchitecture impairment observed 6 months post-KTx may reflect subtle albeit present post-KTx CKD-MBD. What is Known? • Mineral bone disorder associated with chronic kidney disease (CKD-MBD) frequently persists after kidney transplantation (KTx) and is associated with morbidity. However, biochemical parameters and dual X-ray absorptiometry (DXA) are poor predictors of the underlying bone disease. What is new? • The present study on 19 adolescent KTx recipients with adequate CKD-MBD control at the time of KTx reveals no significant bone disease compared to matched healthy controls. Microarchitecture impairment observes 6 months post-KTx may reflect subtle, albeit present, post-KTx CKD-MBD.
Authors
- Aurélie De Mul (ORCID: https://orcid.org/0000-0002-7658-3068)
- Tiphanie Ginhoux
- Justine Bacchetta (ORCID: https://orcid.org/0000-0002-0578-2529)
- Manon Aurelle (ORCID: https://orcid.org/0000-0002-7523-5854)
- Cyrille B. Confavreux (ORCID: https://orcid.org/0000-0002-9318-6785)
- Aurélie Portefaix (ORCID: https://orcid.org/0000-0003-4981-821X)
- Anne-Laure Leclerc
- C. Levi
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Hôpital Femme Mère Enfant (FR)
- Hospices Civils de Lyon (FR)
- Hôpital Edouard Herriot (FR)
- Physiopathologie, diagnostic et traitements des maladies musculo-squelettiques (FR)
- Laboratoire de Biométrie et Biologie Evolutive (FR)
Publication Details
- Journal
- European Journal of Pediatrics
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1007/s00431-024-05777-z
- Citations
- 1
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- Agence de la Biomédecine
- Hospices Civils de Lyon