Alterations in peripheral T‐cell and B‐cell subsets in the ankylosing spondylitis patients with gut inflammation
Distinct immune patterns may exist in AS with different types of intestinal inflammation. Colitis in AS is primarily characterized by a significant increase in exhausted CD4<sup>+</sup> T cells, along with a decrease in Th2 cells. In contrast, terminal ileum inflammation in AS is marked by an increase in total B cells and classic switched B cells. These findings offer new insights for early detection and therapeutic intervention.
Authors
- Ya Xie (ORCID: https://orcid.org/0000-0002-1840-3890)
- Liuzhong Zhou
- Xiqing Luo (ORCID: https://orcid.org/0000-0003-0520-0688)
- Mingcan Yang (ORCID: https://orcid.org/0000-0003-4947-447X)
- Shenghui Wen (ORCID: https://orcid.org/0000-0001-8696-7770)
- Liudan Tu (ORCID: https://orcid.org/0000-0002-2628-6751)
- Jieruo Gu (ORCID: https://orcid.org/0000-0002-8785-0600)
- Qing Lv (ORCID: https://orcid.org/0000-0001-9394-7452)
- Jinwei Li (ORCID: https://orcid.org/0000-0002-6171-4029)
- Xianghui Wen
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- International Journal of Rheumatic Diseases
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1111/1756-185x.15324
- Citations
- 2
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.94