Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia
In summary, usnic acid improves chemosensitivity to ABT-199 by triggering the integrated stress response, leading to decreased levels of MCL-1 protein, suggesting a potential treatment for AML cases resistant to Bcl-2 inhibitors.
Authors
- Yaonan Hong (ORCID: https://orcid.org/0000-0003-1146-0072)
- Dijiong Wu
- Guoyin Kai (ORCID: https://orcid.org/0000-0001-7586-9067)
- Feng Yue (ORCID: https://orcid.org/0000-0002-7954-5462)
- Chengtao Sun
- Shengqian Deng
- Jin Li (ORCID: https://orcid.org/0000-0002-5155-7154)
- Xiaoxiao Han (ORCID: https://orcid.org/0000-0002-0974-8061)
- Liqin Li (ORCID: https://orcid.org/0000-0003-0607-9728)
- Yiping Shen
- Qi Liu
- Man Li (ORCID: https://orcid.org/0000-0002-6695-2384)
Institutions
- Zhejiang Chinese Medical University (CN)
- Huzhou Central Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1016/j.jare.2024.10.003
- Citations
- 6
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Natural Science Foundation of Zhejiang Province