Sex Differences in Skeletal Muscle Pathology in Patients With Heart Failure and Reduced Ejection Fraction
Sex differences in muscle pathology in HFrEF exist, with men showing greater abnormalities compared with women related to the transcriptome, fiber phenotype, capillarity, and circulating factors. These preliminary data question whether muscle pathology is a primary mechanism contributing to greater symptoms in women with HFrEF and highlight the need for further investigation.
Authors
- T. Scott Bowen (ORCID: https://orcid.org/0000-0002-1740-2474)
- Stuart Egginton (ORCID: https://orcid.org/0000-0002-3084-9692)
- Annabel J. Critchlow (ORCID: https://orcid.org/0000-0002-2039-9528)
- Paul W. Hendrickse (ORCID: https://orcid.org/0000-0003-2769-7816)
- Chew W. Cheng
- Sam Straw
- Stephen Bentley Wheatcroft (ORCID: https://orcid.org/0000-0002-6741-9012)
- Nathanael Wood (ORCID: https://orcid.org/0009-0009-7851-1170)
- Klaus K. Witte (ORCID: https://orcid.org/0000-0002-7146-7105)
- Lee D. Roberts (ORCID: https://orcid.org/0000-0002-1455-5248)
- Marcelo G. Pereira (ORCID: https://orcid.org/0000-0002-6670-8031)
Institutions
- University of Leeds (GB)
- Lancaster University (GB)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Circulation Heart Failure
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1161/circheartfailure.123.011471
- Citations
- 9
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 3.62
Funders
- Medical Research Council