Formulation and Characteristics of Film Forming Hydrogel (FFH) of Yellow Root Extract (Arcangelisia Flava (L.) Merr.) As Wound Healing for Burns

The aim of this study was to determine the effect of different concentrations of yellow root extract (Arcangelisia Flava (L.) Merr.) and film-forming hydrogel (FFH) polymer on the physicochemical characteristics and stability of the preparation. The method for making FFH is carried out using varying concentrations (%) of 0,5 extract, 1, and 1,5, as well as variations in concentration (%) of PVP and PVA (2,8:15,2; 2,8:17,2; 2,8:19,2). F1 – F9 were evaluated for physicochemical characteristics, including organoleptic, pH, spreadability, adhesive power, drying time, viscosity, stickiness, and mechanical properties. Next, freeze-thaw stability and data analysis were carried out using the LSD test at a confidence level of 95%. This research indicates that the FFH formulation of yellow root extract has good characteristics in the F1 formula with an extract concentration of 0.5% and a concentration (%) of PVP and PVP polymer (2.8:15.2), which meets all physicochemical characteristic tests. The results of data analysis using SPSS showed that the extract concentration and polymer concentration had a significant effect (0.05<0.05) on the characteristics and stability of the Yellow Root Extract Film Forming Hydrogel (FFH) preparation.