Preparation of Platinum Nanoparticles of Biophytum reinwardtii and Evaluation of Neuroprotective Activity of MPTP-induced Parkinson’s Disease in Zebra Fish

Aim: To evaluate the Neuroprotective activity of Biophytum reinwardtii Platinum nanoparticles Methods: Biophytum reinwerdtii platinum nanoparticles were subjected to evaluation of the neuroprotection activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced zebra fishes. Experimental fishes are divided into 5 groups, each containing 8 fishes. Group I is considered a normal group; Group II is a toxic group means treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 225 mg/kg, i.p. for 5 days; Group III, IV, and V are treatment groups means treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (225 mg/kg) with 0.3 µmol, 0.4µmol, and 0.5 µmol of Biophytum reinwardtii Platinum nanoparticles respectively for 5 days. Results: In the in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine group, locomotor activity and complex I activity are decreased, Malondialdehyde levels increased, antioxidants, and catecholamines levels decreased, whereas Biophytum reinwardtii Platinum nanoparticles treated fishes exhibit significant locomotor and increased levels of antioxidants and catecholamines. Conclusion: These results suggest that Biophytum reinwardtii Platinum nanoparticles. Showed significant neuroprotection activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine -induced Parkinson’s zebra fishes.