Antibodies to specific domains of <i>Plasmodium falciparum</i> erythrocyte membrane protein‐1 and its relationship with protection from severe malarial anemia: A prospective study among Ghanaian children
The high prevalence of <i>Pf</i>EMP-1 IgG antibodies to DBLα2, CIDRα1, DBLβ12, and DBLγ6 domains observed in participants with uncomplicated malaria, and the relationship between <i>Pf</i>EMP-1 IgG antibodies and blood cell parameters could indicate that the antibodies may be related to effective erythropoietic response in <i>P. falciparum</i> malaria. Immune antibodies against DBLα2, CIDRα1, DBLβ12, and DBLγ6 domains of <i>Pf</i>EMP-1 may suppress the deteriorating effects of <i>Pf</i>EMP-1 antigens and provide immune protection against severe malarial anemia in children.
Authors
- Gabriel Abbam (ORCID: https://orcid.org/0000-0002-0408-6126)
- Victor Udoh Usanga (ORCID: https://orcid.org/0000-0001-6185-1683)
- Ejike Felix Chukwurah (ORCID: https://orcid.org/0000-0001-5485-3453)
- Samira Daud (ORCID: https://orcid.org/0000-0003-0133-1760)
- Boniface Nwofoke Ukwah (ORCID: https://orcid.org/0000-0002-5203-4056)
- Simon Bannison Bani (ORCID: https://orcid.org/0000-0002-6713-6653)
- Charles A. Derigubah (ORCID: https://orcid.org/0000-0003-1519-3530)
- Dorcas Serwaa (ORCID: https://orcid.org/0000-0001-8583-4415)
- Samuel Kwasi Appiah
- Charles Nkansah (ORCID: https://orcid.org/0000-0001-6986-9976)
- Felix Osei‐Boakye (ORCID: https://orcid.org/0000-0001-5126-7424)
- Bright Boakye (ORCID: https://orcid.org/0009-0009-7537-3913)
- Samsiyatu Abdulai (ORCID: https://orcid.org/0009-0001-2166-7918)
- Emmanuel Appiah‐Kubi (ORCID: https://orcid.org/0009-0009-6589-4184)
- Anastasia Koduah
- Neena I. Anass (ORCID: https://orcid.org/0009-0003-7872-4420)
- Emmanuel K. Alhassan (ORCID: https://orcid.org/0009-0000-2849-3845)
- Isaac Adjei (ORCID: https://orcid.org/0009-0001-5907-224X)
Institutions
- The University of Melbourne (AU)
- Sunyani Technical University (GH)
- Bolgatanga Technical University
- University for Development Studies (GH)
- Ebonyi State University (NG)
Publication Details
- Journal
- Health Science Reports
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/hsr2.70123
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00