Temporal Effect on <scp>PD</scp>‐<scp>L1</scp> Detection and Novel Insights Into Its Clinical Implications in Non–Small Cell Lung Cancer
PD-L1 detection from tissue blocks was found to vary temporally, urging for a prioritized consideration for patients with marginal scores when archived blocks are employed for its detection. Prognostic roles of PD-L1 were associated with driver mutations, and KRAS mutations favored the outcome of anti-PD-L1/PD1 therapy in advanced NSCLC.
Authors
- Mathieu Castonguay
- Alison Wallace (ORCID: https://orcid.org/0000-0001-5591-3809)
- Aneil Mujoomdar
- Alexander Ednie
- Gail Darling (ORCID: https://orcid.org/0000-0001-8430-3516)
- Gopal P. Pathak
- Rashmi R. Shah (ORCID: https://orcid.org/0000-0002-8280-6467)
- Madelaine Plourde (ORCID: https://orcid.org/0000-0002-3365-2043)
- Zhaolin Xu (ORCID: https://orcid.org/0000-0002-8553-4081)
- Angela Cheng (ORCID: https://orcid.org/0000-0002-4386-148X)
- Rowan Murphy
- Harry Henteleff
- Daniel French
- John Fris
Institutions
- Dalhousie University (CA)
- Queen Elizabeth II Health Sciences Centre (CA)
- Health Sciences Centre (CA)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/cam4.70262
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Dalhousie University
- Merck Canada
- Research Nova Scotia