Optimization of the Mineralization Process of Polycaprolactone Fibers with Vaterite Microparticles

Optimization of the process of mineralization of polycaprolactone fibers with vaterite microparticles by varying the concentrations of the working solutions of salts, calcium chloride and sodium carbonate, is proposed. The optimum parameters of mineralization of polycaprolactone fibers with calcium carbonate particles in the vaterite polymorphic modification are found. The effect of the concentrations of the working solutions of the salts and time of ultrasonic treatment on the monodispersity of CaCO3 microparticles present in the composition of the synthesized coating is studied. The concentrations of the working solutions of the salts are varied from 0.25 to 1 mol and the time of US treatment is varied from 30 to 90 s. The obtained tissue-engineered scaffolds can find application in regenerative medicine and for local and prolonged release of drugs. For their successful use for medical purposes, special requirements must be met, namely, the minimum possible polydispersity and the existence of calcium carbonate microparticles in the vaterite polymorphic modification.