Novel insights into the genetic architecture of pregnancy glycemic traits from 14,744 Chinese maternities
Glycemic traits are critical indicators of maternal and fetal health during pregnancy. We performed genetic analysis for five glycemic traits in 14,744 Chinese pregnant women. Our genome-wide association study identified 25 locus-trait associations, including established links between gestational diabetes mellitus (GDM) and the genes CDKAL1 and MTNR1B. Notably, we discovered a novel association between fasting glucose during pregnancy and the ESR1 gene (estrogen receptor), which was validated by an independent study in pregnant women. The ESR1-GDM link was recently reported by the FinnGen project. Our work enhances the findings in East Asian populations and highlights the need for independent studies. Further analyses, including genetic correlation, Mendelian randomization, and transcriptome-wide association studies, provided genetic insights into the relationship between pregnancy glycemic traits and hypertension. Overall, our findings advance the understanding of genetic architecture of pregnancy glycemic traits, especially in East Asian populations.
Authors
- Ying Lin (ORCID: https://orcid.org/0000-0002-3876-5653)
- Huanming Yang (ORCID: https://orcid.org/0000-0002-0858-3410)
- Jingyu Zeng (ORCID: https://orcid.org/0000-0002-9089-3126)
- Aifen Zhou (ORCID: https://orcid.org/0000-0002-1291-4155)
- Zhongqiang Cao (ORCID: https://orcid.org/0000-0003-4315-7588)
- Jieqiong Zhou (ORCID: https://orcid.org/0000-0002-4453-8481)
- Linxuan Li (ORCID: https://orcid.org/0000-0002-7920-4684)
- Hong Mei (ORCID: https://orcid.org/0000-0002-9084-8325)
- Jiuying Liu
- Liqin Hu (ORCID: https://orcid.org/0000-0002-1284-7271)
- Xiao Han (ORCID: https://orcid.org/0000-0001-9262-7254)
- Xiaonan Cai
- Yan Zhou (ORCID: https://orcid.org/0000-0001-5089-5963)
- Xianmei Lan
- Panhong Liu
- Zhuangyuan Tang
- Rui Zhou (ORCID: https://orcid.org/0000-0001-5373-6917)
- Jian Wang (ORCID: https://orcid.org/0000-0002-9482-5227)
- Xinyi Zhang (ORCID: https://orcid.org/0000-0001-7933-502X)
- Xun William Xu (ORCID: https://orcid.org/0000-0001-6294-8153)
- Qian Xiaobo
- Meng Yang (ORCID: https://orcid.org/0000-0003-0063-7100)
- Mingzhi Cai (ORCID: https://orcid.org/0009-0003-4043-9640)
- Yuanyuan Zhong (ORCID: https://orcid.org/0000-0002-9609-1626)
- Huanhuan Zhu (ORCID: https://orcid.org/0000-0002-9833-2665)
- Xin Jin
- Lin Wang (ORCID: https://orcid.org/0000-0003-3033-4792)
Institutions
- BGI Group (China) (CN)
- Shanxi Medical University (CN)
- North West Agriculture and Forestry University (CN)
- Botswana Geoscience Institute (BW)
- Wuhan Children's Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- BGI Research (CN)
- Huazhong University of Science and Technology (CN)
- Northwest A&F University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Cell Genomics
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1016/j.xgen.2024.100631
- Citations
- 10
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 5.83
Funders
- National Natural Science Foundation of China