Human pegivirus -1 (HPgV-1) RNA frequency and genotype distribution in pediatric oncology patients with febrile neutropenia
Human Pegivirus-1, typically regarded as a commensal virus, exhibits high prevalence in humans. Its frequency and impact on oncologic pediatric patients with febrile neutropenia (FN), a frequent chemotherapy complication, remains unexplored. In this study, we assessed HPgV-1 RNA prevalence in pediatric patients experiencing FN. Blood samples were collected from 30 children, 15 presenting FN and 15 comprising a control group of either undergoing treatment or in remission. Overall, HPgV-1 RNA was detected in 23.3 % of samples (26.7 % among FN patients and 20.0 % among those under treatment or in remission). Phylogenetic analysis unveiled HPgV-1 genotype 2 predominance among these samples, the most prevalent strain circulating in Brazil. Our findings prompt crucial inquiries into the role of HPgV-1 RNA in FN: is it an incidental finding and if it can influences this clinical entity? Further investigation is imperative to elucidate HPgV-1 implications in vulnerable patients cohorts, potentially informing new approaches and understanding viral dynamics in immunocompromised populations.
Authors
- Maria Carolina Elias (ORCID: https://orcid.org/0000-0002-0501-8280)
- Gabriel Montenegro de Campos (ORCID: https://orcid.org/0000-0001-5181-415X)
- Anielly Sarana da Silva (ORCID: https://orcid.org/0000-0001-5134-1460)
- Gabriela Marengone Altizani (ORCID: https://orcid.org/0000-0003-4264-1714)
- Simone Kashima (ORCID: https://orcid.org/0000-0002-1487-0141)
- Svetoslav Nanev Slavov (ORCID: https://orcid.org/0000-0003-0805-6140)
- Marta Giovanetti (ORCID: https://orcid.org/0000-0002-5849-7326)
- Dennis Maletich Junqueira (ORCID: https://orcid.org/0000-0003-1576-484X)
- Sandra Coccuzzo Sampaio (ORCID: https://orcid.org/0000-0001-6257-3531)
- Carlos Alberto Scrideli (ORCID: https://orcid.org/0000-0001-6618-789X)
- Alice Chagas Barros
Institutions
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- Instituto Butantan (BR)
- Universidade Federal de Santa Maria (BR)
- Department of Science and Technology and Biotechnology (IN)
- Clinics Hospital of Ribeirão Preto (BR)
Publication Details
- Journal
- Virus Research
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1016/j.virusres.2024.199479
- Citations
- 2
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico