Considering best practice standards for routine whole-genome sequencing for TB care and control
TB is a priority pathogen for the application of whole-genome sequencing (WGS) into routine public health practice. In low-incidence settings, a growing number of services have begun to incorporate routine WGS into standard practice. The increasing availability of real-time genomic information supports a variety of aspects of the public health response, including the detection of drug resistance, monitoring of laboratory and clinical practices, contact tracing investigations and active case finding. Optimal structures and approaches are needed to support the rapid translation of genomic information into practice and to evaluate outcomes and impact. In this consensus paper, we outline the elements needed to systemically incorporate routine WGS into the TB public health response, including the sustainability of services, multidisciplinary team models and monitoring and evaluation frameworks. If integrated in an efficient and thoughtful manner, routine WGS has the potential to significantly improve clinical TB care for individuals and the overall public health response.
Authors
- Lisa Trieu (ORCID: https://orcid.org/0000-0002-6039-9223)
- Matthijs Backx (ORCID: https://orcid.org/0000-0002-4162-4405)
- Richard Lee (ORCID: https://orcid.org/0000-0003-4687-1381)
- Justin T. Denholm (ORCID: https://orcid.org/0000-0002-9214-6431)
- Jun Yang Tay (ORCID: https://orcid.org/0000-0003-1150-8814)
- Ben J. Marais (ORCID: https://orcid.org/0000-0003-3404-2690)
- Ellen Donnan (ORCID: https://orcid.org/0000-0002-0497-6970)
- Esther Robinson (ORCID: https://orcid.org/0009-0003-0913-3627)
- Richard Anthony (ORCID: https://orcid.org/0000-0002-0550-5273)
- Gèrard de Vries (ORCID: https://orcid.org/0000-0003-1278-4503)
- Jeanne Sullivan Meissner
- Herns Modestil
- Honghui Lin (ORCID: https://orcid.org/0000-0003-0781-3330)
- Amie-Louise Seagar
- Vitali Sintchenko (ORCID: https://orcid.org/0000-0002-9261-3650)
- Deborah HL Ng
- Ian F. Laurenson
Institutions
- The University of Sydney (AU)
- New South Wales Department of Health (AU)
- New York City Department of Health and Mental Hygiene (US)
- The University of Melbourne (AU)
- National Taiwan University (TW)
- University Hospital of Wales (GB)
- Taronga Conservation Society Australia (AU)
- McGill University Health Centre (CA)
- Edinburgh Royal Infirmary (GB)
- National Institute for Public Health and the Environment (NL)
- Peter Doherty Institute (AU)
- National Centre for Infectious Diseases (SG)
Publication Details
- Journal
- IJTLD OPEN
- Published
- 2024-10-01
- DOI
- https://doi.org/10.5588/ijtldopen.24.0320
- Citations
- 11
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.89