Neuroprotective effects of all-trans-retinoic acid are mediated via downregulation of TLR4/NF-κB signaling in a rat model of middle cerebral artery occlusion
The ATRA treatment promoted functional recovery in an experimental model of ischemic stroke by attenuating neural inflammation. ATRA potentially modulated microglia-mediated neuroinflammation via the downregulation of the TLR4/NF-κB signaling pathway, which makes it a candidate treatment for post-stroke neuroinflammation.
Authors
- Rongjiao You
- Songfa Chen
- Zhongxing Peng (ORCID: https://orcid.org/0000-0002-5773-5599)
- Xinyue Li (ORCID: https://orcid.org/0009-0005-9543-9888)
- L. B. Tan
- Tao Wen (ORCID: https://orcid.org/0000-0002-6944-0739)
- Qian Liu (ORCID: https://orcid.org/0000-0001-5341-1290)
Institutions
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
Publication Details
- Journal
- Neurosciences
- Published
- 2024-10-01
- DOI
- https://doi.org/10.17712/nsj.2024.4.20240010
- Citations
- 3
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.70