Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics
Using simulations, different empirical dosing regimens were proposed to achieve plasma quinidine concentrations immediately or progressively, representing a tradeoff between optimizing therapeutic effects and minimizing adverse effects. A combination of these dosing regimens is recommended to gradually increase the therapeutic concentration levels of quinidine for safe and effective treatment of AF in racehorses.
Authors
- Yūji Takahashi (ORCID: https://orcid.org/0000-0002-9776-2647)
- Hiroshi Mita (ORCID: https://orcid.org/0000-0003-2201-9733)
- Norihisa Tamura (ORCID: https://orcid.org/0000-0002-9138-6839)
- Toshio Nukada
- Taisuke Kuroda (ORCID: https://orcid.org/0000-0002-3709-5459)
- Yusaku Ebisuda (ORCID: https://orcid.org/0000-0002-9165-6835)
- Hiroshi Ishikawa (ORCID: https://orcid.org/0000-0001-6310-5748)
- Minoru Ohta (ORCID: https://orcid.org/0000-0001-8131-5044)
- Yohei Minamijima (ORCID: https://orcid.org/0000-0002-2096-0784)
- Pierre‐Louis Toutain (ORCID: https://orcid.org/0000-0002-8846-8892)
- Christopher Ken Kinman
- Kaori Inoue (ORCID: https://orcid.org/0009-0007-8770-2011)
Institutions
- Royal Veterinary College (GB)
- École Nationale Vétérinaire de Toulouse (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Laboratory of Racing Chemistry (JP)
- Japan Racing Association (JP)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2024-10-07
- DOI
- https://doi.org/10.3389/fvets.2024.1454342
- Citations
- 2
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Japan Racing Association